Non coding RNA therapeutics in the treatment of heart failure.

Aleksandra PaterekMarta Załęska-KocięckaMateusz SurzykiewiczZuzanna WojdyńskaPrzemysław LeszekMichał Mączewski

Published in: European heart journal. Cardiovascular pharmacotherapy (2024)

ncRNA therapeutics can target either ncRNAs or conventional mRNA, offering both superior pharmacokinetics and selectivity to conventional therapies and addressing new, previously unexplored pathways. Although no ncRNA has yet been approved for the treatment of heart failure, in this review we present 5 most promising pathways and agents that are either in human clinical trials or offer great promise in the near future.

Keyphrases

heart failure
clinical trial
small molecule
left ventricular
atrial fibrillation
randomized controlled trial
acute heart failure
big data
artificial intelligence
smoking cessation
nucleic acid
drug administration