PPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia.

Tarik ZahrLonghua LiuMichelle ChanQiuzhong ZhouBishuang CaiYing HeNicole AaronDomenico AcciliLei SunLi Qiang

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

PPARγ deacetylation in mice prevents the development of aging-associated atherosclerosis and hypercholesterolemia, in association with the anti-inflammatory phenotype of 2KR macrophages.

Keyphrases

anti inflammatory
cardiovascular disease
insulin resistance
cardiovascular events
high fat diet induced
signaling pathway
fatty acid
low density lipoprotein
mouse model
type diabetes