Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heart.
Ziwen LiEmmanouil G SolomonidisBronwyn BerkeleyMichelle Nga Huen TangKatherine Ross StewartDaniel Perez-VicencioIan R McCrackenAna Mishel SpiroskiGillian A GrayAnna K BartonStephanie L SellersPaul R RileyAndrew H BakerMairi BrittanPublished in: Cardiovascular research (2022)
Myocardial infarction is the leading cause of heart failure, a condition with high morbidity and mortality. Vascular regeneration is vital to tissue survival and functional restoration while a comprehensive understanding of the underpinning mechanisms is lacking. We show that the meta-analysis of single cell RNA-sequencing data excels at deciphering multi-faceted vascular responses conserved between mouse and human following ischaemic injury. We envision that these data will inform future strategies and accelerate therapeutic development for promoting vascular regeneration in the ischaemic heart.
Keyphrases
- heart failure
- single cell
- stem cells
- left ventricular
- endothelial cells
- systematic review
- electronic health record
- rna seq
- genome wide
- transcription factor
- atrial fibrillation
- big data
- gene expression
- cardiac resynchronization therapy
- high throughput
- randomized controlled trial
- wound healing
- current status
- acute heart failure