Calcium/calmodulin-dependent kinases can regulate the TSH expression in the rat pituitary.

Giovanna Giuseppina Altobelli Susan Van Noorden Donatella Cimini Maddalena Illario Daniela Sorriento Vincenzo Cimini

Published in: Journal of endocrinological investigation (2021)

Our data indicate that the expression of Ca2+/CaMK in rat anterior pituitary are correlated to the role of CREB in the genetic regulation of TSH, and that TRH stimulation activates CaMKIV, which in turn phosphorylates CREB. This phosphorylation is linked to the production of thyrotropin.

Keyphrases

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