Association of bone morphogenetic protein 6 with exocrine gland dysfunction in patients with Sjögren's syndrome and in mice.

Hongen YinJavier Cabrera-PerezZhenan LaiDrew MichaelMelodie WellerWilliam D SwaimXibao LiuMarcelo A CatalánEduardo M RochaNevien IsmailSandra AfioneNoreen A RanaGiovanni Di PasqualeIlias AlevizosIndu AmbudkarGabor G IlleiJohn A Chiorini

Published in: Arthritis and rheumatism (2014)

In addition to identifying BMP-6 expression in association with xerostomia and xerophthalmia in primary SS, the present results suggest that BMP-6-induced salivary and lacrimal gland dysfunction in primary SS is independent of the autoantibodies and immune activation associated with the disease.

Keyphrases

mesenchymal stem cells
oxidative stress
poor prognosis
systemic lupus erythematosus
bone regeneration
type diabetes
adipose tissue
high fat diet induced
binding protein
bone marrow
long non coding rna
wild type
stress induced