The Effectiveness of Imipenem-Relebactam against Ceftazidime-Avibactam Resistant Variants of the KPC-2 β-Lactamase.

Krisztina M Papp-WallaceMelissa D BarnesMagdalena A TaracilaChristopher R BethelJoseph D RutterElise T ZeiserKatherine YoungRobert A Bonomo

Published in: Antibiotics (Basel, Switzerland) (2023)

Imipenem-relebactam overcame the resistance of the D179 variants, suggesting that this combination will be active against clinical isolates harboring these derivatives of KPC-2.

Keyphrases

klebsiella pneumoniae
multidrug resistant
copy number
escherichia coli
gram negative
randomized controlled trial
systematic review