Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration.
Ayako SuzukiHans TillmannJames WilliamsRonald G HauserJulie FrundMizuki SuzukiFred W PriorGuruprasad Padur AithalMaría Isabel LucenaRaúl Jesús AndradeWeida TongChristine M HuntPublished in: Drug safety (2022)
This framework identifies unexplained acute liver injury following drug exposure in large electronic health record datasets. After validating in other systems, this framework can aid in deducing drug-induced liver injury in the general patient population and regulatory decision making to promote drug safety and public health.
Keyphrases
- drug induced
- liver injury
- public health
- electronic health record
- adverse drug
- end stage renal disease
- decision making
- chronic kidney disease
- newly diagnosed
- healthcare
- ejection fraction
- mental health
- clinical decision support
- prognostic factors
- liver failure
- peritoneal dialysis
- gene expression
- case report
- genome wide
- patient reported outcomes
- risk assessment
- health information
- dna methylation
- global health
- extracorporeal membrane oxygenation
- adipose tissue
- rna seq
- patient reported
- health promotion