Metformin induces apoptosis in mesenchymal stromal cells and dampens their therapeutic efficacy in infarcted myocardium.
Xiao HeMeng-Wei YaoMing ZhuDong-Lan LiangWei GuoYi YangRong-Seng ZhaoTing-Ting RenXiang AoWei WangChun-Yu ZengHua-Ping LiangDong-Po JiangJian YuXiang XuPublished in: Stem cell research & therapy (2018)
Our results highlight an unexpected adverse effect of metformin-induced MSC apoptosis through AMPK-mediated mTOR suppression, which is attenuated by an AMPK inhibitor. Moreover, AMPK inhibition may be a novel strategy for enhancing the effectiveness of stem cell therapy after MI in diabetes.
Keyphrases
- cell therapy
- skeletal muscle
- protein kinase
- type diabetes
- stem cells
- randomized controlled trial
- oxidative stress
- cardiovascular disease
- high glucose
- bone marrow
- systematic review
- endoplasmic reticulum stress
- diabetic rats
- cell death
- cell proliferation
- metabolic syndrome
- emergency department
- adipose tissue
- endothelial cells