In vivo anti-inflammatory activity of Fabaceae species extracts screened by a new ex vivo assay using human whole blood.
Welton RosaOlívia da S DomingosPaula Pio de Oliveira SalemIvo Santana CaldasAnna Maria A P FernandesJoão Henrique Ghilardi LagoPatricia SartorelliDanielle Ferreira DiasDaniela Aparecida Chagas de PaulaMarisi Gomes SoaresPublished in: Phytochemical analysis : PCA (2021)
The quantification method for PGE2 demonstrated fast, sensitive, precise, and accurate results. The new ex vivo anti-inflammatory assay comprised a great, reliable, and ethical approach for the screening of a large number of samples before an in vivo bioassay. Additionally, the four active extracts in both ex vivo and in vivo assays may be useful for the development of more efficient anti-inflammatory drugs.