Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Christian HinzeChristine KocksJanna LeizNikos KaraiskosAnastasiya BoltengagenShuang CaoChristopher Mark SkopnikJan KlockeJan-Hendrik B HardenbergHelena StockmannInka GotthardtBenedikt ObermayerLaleh HaghverdiEmanuel WylerMarkus LandthalerSebastian BachmannAndreas C HockeVictor CormanJonas BuschWolfgang SchneiderNina HimmerkusMarkus BleichKai Uwe EckardtPhilipp EnghardNikolaus RajewskyKai M Schmidt-OttPublished in: Genome medicine (2022)
The study provides an extensive resource of the cell type-specific transcriptomic responses associated with critical illness-associated AKI in humans, highlighting recurrent disease-associated signatures and inter-individual heterogeneity. Personalized molecular disease assessment in human AKI may foster the development of tailored therapies.