FOXO1 regulates Th17 cell-mediated hepatocellular carcinoma recurrence after hepatic ischemia-reperfusion injury.
Hao-Zhen RenYuyan ChenZhengyi ZhuJinkun XiaShujun LiuYingzhe HuXueqian QinLu ZhangYitao DingSenzhe XiaJing-Lin WangPublished in: Cell death & disease (2023)
These results indicated that FOXO1-Th17/Treg axis exerts a crucial role in IRI-mediated immunologic derangement and HCC recurrence, which could be a promising target for reducing the HCC recurrence after hepatectomy. Liver IRI affects the balance of Th17/Treg cells by inhibiting the expression of FOXO1, and the increase of Th17 cells has the ability to induce HCC recurrence through EMT program, cancer stemness pathway, the formation of premetastatic microenvironment and angiogenesis.
Keyphrases
- induced apoptosis
- signaling pathway
- cell cycle arrest
- pi k akt
- transcription factor
- ischemia reperfusion injury
- stem cells
- epithelial mesenchymal transition
- poor prognosis
- endoplasmic reticulum stress
- oxidative stress
- single cell
- quality improvement
- binding protein
- endothelial cells
- long non coding rna
- cell proliferation
- young adults
- vascular endothelial growth factor