Genomic Landscape of Vinflunine Response in Metastatic Urothelial Cancer.

Alejandra Bernardini Marta DueñasMaría Cruz Martín-SoberonCarolina RubioCristian Suarez-CabreraRaquel Ruiz-PalomaresEster Munera-MaravillaSara LázaroIris Lodewijk Daniel Rueda David Gómez-Sánchez Teresa Alonso Gordoa Javier Puente VázquezÁlvaro PintoPilar González-PeramatoCarlos AguadoMercedes HerreraFlora LópezVictor M G MartinezLucía MoralesDaniel CastellanoJesus M ParamioGuillermo de Velasco

Published in: Cancers (2022)

Our data may help to identify potential genomic biomarkers of response to vinflunine. Moreover, tumours refractory to vinflunine showed immune signatures potentially associated with response to ICB. Extensive validation studies, including longitudinal series, are needed to corroborate these findings.

Keyphrases

copy number
papillary thyroid
squamous cell carcinoma
small cell lung cancer
squamous cell
electronic health record
genome wide
high grade
cross sectional
lymph node metastasis
urinary tract
human health
gene expression
dna methylation
machine learning
childhood cancer