Plant-Derived Vesicle-Like Nanoparticles: Clinical Application Exploration and Challenges.
Wenfang HeSiqiang ZhengHua ZhangBowen GaoJuan JinMingzhen ZhangQiang HePublished in: International journal of nanomedicine (2023)
The utilization of plant-derived vesicle-like nanoparticles (PDVLNs) has shown effectiveness in the prevention/treatment of inflammatory-mediated diseases, malignancies, and immune-related diseases, such as acute liver injury, allergic asthma, gastric cancer and so on. This highlights the promising potential of PDVLNs as biotherapeutics. Furthermore, it should be noted that PDVLNs possess the ability to function as both natural and engineered drug carriers, making them an appealing option. This review aims to present the appropriate extraction methods of PDVLNs, summarize the applications of PDVLNs in different diseases, and provide an outlook on the prospects of PDVLNs. At the same time, the authors also express their discussion on the current limitations of PDVLNs.
Keyphrases
- drug induced
- liver injury
- randomized controlled trial
- systematic review
- liver failure
- adverse drug
- allergic rhinitis
- emergency department
- lung function
- cell wall
- human health
- risk assessment
- respiratory failure
- walled carbon nanotubes
- acute respiratory distress syndrome
- climate change
- cystic fibrosis
- atopic dermatitis