Long-term test-retest of cerebral [18F]MK-6240 binding and longitudinal evaluation of extracerebral tracer uptake in healthy controls and amnestic MCI patients.

Greet VanderlindenNathalie MertensLaura MichielsRobin LemmensMichel KooleMathieu VandenbulckeKoen Van Laere

Published in: European journal of nuclear medicine and molecular imaging (2022)

[18F]MK-6240 shows excellent 6-month TRT, which confirms its suitability for quantification of longitudinal NFT changes. The ECU of [18F]MK-6240 is variable between subjects, influenced by age and sex, but remains stable within subjects over a 2-year time period.

Keyphrases

mild cognitive impairment
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
cross sectional
peritoneal dialysis
prognostic factors
patient reported outcomes
computed tomography
positron emission tomography
brain injury
binding protein
cerebral blood flow