Parameterization of Acyclic Diaminocarbene Ligands Applied to a Gold(I)-Catalyzed Enantioselective Tandem Rearrangement/Cyclization.
Zachary L NiemeyerSuresh PindiDimitri A KhrakovskyChristian N KuzniewskiCynthia M HongLeo A JoyceMatthew S SigmanF Dean TostePublished in: Journal of the American Chemical Society (2017)
Computed descriptors for acyclic diaminocarbene ligands are developed in the context of a gold catalyzed enantioselective tandem [3,3]-sigmatropic rearrangement-[2+2]-cyclization. Surrogate structures enable the rapid identification of parameters that reveal mechanistic characteristics. The observed selectivity trends are validated in a robust multivariate analysis facilitating the development of a highly enantioselective process.