The scaffolding protein DLG5 promotes glioblastoma growth by controlling Sonic Hedgehog signaling in tumor stem cells.

Somanath KunduMohan S NandhuSharon L LongoJohn A LongoShawn RaiLawrence S ChinTimothy E RichardsonMariano S Viapiano

Published in: Neuro-oncology (2022)

The high expression and pro-tumoral functions of DLG5 in glioblastoma, including its dominant regulation of Shh signaling in tumor stem cells, reveal a novel role for this protein that is strikingly different from its proposed tumor-suppressor role in other solid tumors.

Keyphrases

stem cells
binding protein
poor prognosis
protein protein
cell therapy
gene expression
small molecule
anti inflammatory
bone marrow