Pontine gliomas a 10-year population-based study: a report from The Canadian Paediatric Brain Tumour Consortium (CPBTC).

Adriana FonsecaSamina AfzalLynette BowesBruce CrooksValerie LaroucheNada JabadoSebastien PerreaultDonna L JohnstonShayna ZelcerAdam FlemingKatrin ScheinemannMariana SilvaMagimairajan Issai VananChris MpofuBeverly WilsonDavid D EisenstatLucie Lafay-CousinJuliette HukinCynthia HawkinsUte BartelsEric Bouffet

Published in: Journal of neuro-oncology (2020)

Our study highlights the challenges associated with epidemiology studies on DIPG and the importance of central review for incidence rate estimations. It emphasizes that tissue biopsies are required for accurate histological and molecular diagnosis in patients presenting with pontine lesions and reinforces the limitations of radiological and clinical diagnosis in DIPG. Likewise, it underscores the urgent need to increase the availability and accessibility to clinical trials.

Keyphrases

clinical trial
risk factors
intensive care unit
high grade
white matter
high resolution
resting state
multiple sclerosis
randomized controlled trial
open label
phase ii
phase iii
cerebral ischemia