Endothelin-1 (ET-1) induces resistance to bortezomib in human multiple myeloma cells via a pathway involving the ETB receptor and upregulation of proteasomal activity.

Maria VaiouEvanthia PangouPanagiotis LiakosNikos SakellaridisGeorge VassilopoulosKonstantinos DimasChristos Papandreou

Published in: Journal of cancer research and clinical oncology (2016)

Our data suggest a possible role of the ET-1/ETBR axis in regulating the sensitivity of MM cells to BTZ. Thus, combining bortezomib with strategies to target the ET-1 axis could prove to be a novel promising therapeutic approach in MM.

Keyphrases

multiple myeloma
induced apoptosis
cell cycle arrest
endothelial cells
endoplasmic reticulum stress
cell death
cell proliferation
poor prognosis
machine learning
newly diagnosed
big data
electronic health record
deep learning
binding protein