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Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C.

Paul MartinAmanda McGovernJonathan MasseyStefan SchoenfelderKate DuffusAnnie YarwoodAnne BartonJane WorthingtonPeter FraserStephen EyreGisela Orozco
Published in: PloS one (2016)
These results suggest that the four 6q23 variants, independently associated with MS, are involved in the regulation of several genes, including immune genes. These findings could help understand mechanisms of disease and suggest potential novel therapeutic targets.
Keyphrases
  • multiple sclerosis
  • genome wide
  • genome wide identification
  • bioinformatics analysis
  • mass spectrometry
  • copy number
  • genome wide analysis
  • white matter
  • dna methylation
  • transcription factor