Traditional Chinese Medicine Shi-Bi-Man regulates lactic acid metabolism and drives hair follicle stem cell activation to promote hair regeneration.

Haojie DuTao ZhangQiao WangXinran CaoHuiwen ZhengJiabin LiJianxia ZhuJiao QuLehang GuoYang Sun

Published in: Chinese medicine (2023)

SBM significantly promotes hair regeneration in cynomolgus monkeys. Mechanically, SBM can up-regulate LDHA-mediated lactic acid metabolism and drive HFSC activation, which in turn promotes the proliferation and differentiation of HFSCs.

Keyphrases

lactic acid
stem cells
signaling pathway
cell therapy
fluorescent probe
living cells
mesenchymal stem cells
quantum dots