HSPA4 upregulation induces immune evasion via ALKBH5/CD58 axis in gastric cancer.
Daqin SuoXiaoling GaoQingyun ChenTingting ZengJiarong ZhanGuanghui LiYinli ZhengSenlin ZhuJingping YunXin-Yuan GuanYan LiPublished in: Journal of experimental & clinical cancer research : CR (2024)
T cell's cytotoxicity, finally induces immune evasion of GC cells. HSPA4 upregulation is associated with worse overall survival of GC patients with only surgery. Meanwhile, HSPA4 upregulation predicts for better response in GC patients receiving the combined immunotherapy.
Keyphrases
- poor prognosis
- heat shock protein
- cell proliferation
- signaling pathway
- induced apoptosis
- gas chromatography
- minimally invasive
- cell cycle arrest
- coronary artery bypass
- long non coding rna
- surgical site infection
- coronary artery disease
- mass spectrometry
- oxidative stress
- pi k akt
- free survival
- acute coronary syndrome
- percutaneous coronary intervention