Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE).
Heidi T M LaiFumiaki ImamuraAndres V Ardisson KoratRachel A MurphyNathan TintleJulie K BassettJiaying ChenJanine KrögerKuo Liong ChienMackenzie SennAlexis C WoodNita G ForouhiMatthias Bernd SchulzeWilliam S HarrisRamachandran S VasanFrank HuGraham G GilesAllison HodgeLuc DjousseIngeborg A BrouwerFrank QianQi SunJason H Y WuMatti MarklundRozenn N LemaitreDavid S SiscovickAmanda M FrettsAladdin H ShadyabJoAnn E MansonBarbara V HowardJennifer G RobinsonRobert B WallaceNick J WarehamYii-Der Ida ChenJerome I RotterMichael Y TsaiRenata MichaDariush Mozaffariannull nullPublished in: Diabetes care (2022)
Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.