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Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE).

Heidi T M LaiFumiaki ImamuraAndres V Ardisson KoratRachel A MurphyNathan TintleJulie K BassettJiaying ChenJanine KrögerKuo Liong ChienMackenzie SennAlexis C WoodNita G ForouhiMatthias Bernd SchulzeWilliam S HarrisRamachandran S VasanFrank HuGraham G GilesAllison HodgeLuc DjousseIngeborg A BrouwerFrank QianQi SunJason H Y WuMatti MarklundRozenn N LemaitreDavid S SiscovickAmanda M FrettsAladdin H ShadyabJoAnn E MansonBarbara V HowardJennifer G RobinsonRobert B WallaceNick J WarehamYii-Der Ida ChenJerome I RotterMichael Y TsaiRenata MichaDariush Mozaffariannull null
Published in: Diabetes care (2022)
Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.
Keyphrases
  • fatty acid
  • type diabetes
  • cardiovascular disease
  • healthcare
  • public health
  • mental health
  • drinking water
  • glycemic control
  • risk assessment
  • adipose tissue
  • insulin resistance
  • wastewater treatment
  • single molecule