The type I interferon antiviral response in the choroid plexus and the cognitive risk in COVID-19.
Stefano SuzziAfroditi Tsitsou-KampeliMichal SchwartzPublished in: Nature immunology (2023)
The type I interferon (IFN) response is the body's typical immune defense against viruses. Previous studies linked high expression of genes encoding type I IFNs in the brain's choroid plexus to cognitive decline under virus-free conditions in aging and neurodegeneration. Multiple reports have documented persisting cognitive symptoms following recovery from COVID-19. Cumulative evidence shows that the choroid plexus is one of the brain regions most vulnerable to infection with the coronavirus SARS-CoV-2, and manifests increased expression of genes encoding type I IFNs even in the absence of viral traces within the brain. In this Perspective, we propose that the type I IFN defensive immune response to SARS-CoV-2 infection in the choroid plexus poses a risk to cognitive function if not resolved in a timely manner.
Keyphrases
- sars cov
- cognitive decline
- respiratory syndrome coronavirus
- ultrasound guided
- dendritic cells
- resting state
- poor prognosis
- white matter
- coronavirus disease
- mild cognitive impairment
- functional connectivity
- immune response
- genome wide
- multiple sclerosis
- long non coding rna
- gene expression
- sleep quality
- depressive symptoms
- subarachnoid hemorrhage
- breast cancer risk