Activation of TRPM8 channel inhibits contraction of the isolated human ureter.

Jiaxin LiuLei LiuMengmeng ZhaoNing DingNan GeStephanie L DaughertyJonathan M BeckelShaoyong WangXiulin Zhang

Published in: Neurourology and urodynamics (2021)

The TRPM8 channel expressed on sensory nerve terminals of the human ureter is involved in the inhibitory sensory neurotransmission and modulate ureter contraction via the CGRP-adenylyl cyclase-protein kinase A pathway. TRPM8 may be involved in stone-induced changes in ureter contraction or pain.

Keyphrases

endothelial cells
urinary tract
smooth muscle
induced pluripotent stem cells
protein kinase
chronic pain
pluripotent stem cells