Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma.

Maria F Gonzalez-Aponte Anna R Damato Laura Lucía Trebucq Tatiana Simon Sandra P Cárdenas-García Kevin Cho Gary J Patti Diego Andrés Golombek Juan José Chiesa Joshua B Rubin Erik D Herzog

Published in: Journal of neuro-oncology (2024)

We conclude that chemotherapy with TMZ can be dramatically enhanced by delivering at the daily maximum of tumor Bmal1 expression and minimum of MGMT activity and that scoring MGMT methylation status requires controlling for time of day of biopsy.

Keyphrases

poor prognosis
dna methylation
physical activity
genome wide
binding protein
gene expression
transcription factor
squamous cell carcinoma
ultrasound guided
radiation therapy
fine needle aspiration
chemotherapy induced