Login / Signup

Human umbilical cord mesenchymal stem cells conditioned medium exerts anti-tumor effects on KGN cells in a cell density-dependent manner through activation of the Hippo pathway.

Wenjing WanYuyang MiaoYuwei NiuKunyuan ZhuYingwan MaMenghao PanBaohua MaQiang Wei
Published in: Stem cell research & therapy (2023)
The effect of UCMSCs-CM on tumor cells is affected by cell density. UCMSCs-CM exerted anti-tumor effect on KGN cells by activating Hippo pathway to restore contact inhibition. Our results suggest that UCMSCs-CM is a promising therapeutic candidate for GCT treatment.
Keyphrases
  • mesenchymal stem cells
  • umbilical cord
  • induced apoptosis
  • cell therapy
  • cell cycle arrest
  • single cell
  • signaling pathway
  • endothelial cells
  • endoplasmic reticulum stress
  • stem cells
  • cell death
  • pluripotent stem cells