Transformed astrocytes confer temozolomide resistance on glioblastoma via delivering ALKBH7 to enhance APNG expression after educating by glioblastoma stem cells-derived exosomes.

Xinglei LiuLiang LiuAnyi WuShilu HuangZhipeng XuXiaopei ZhangZengyang LiHaoran LiJun Dong

Published in: CNS neuroscience & therapeutics (2024)

The present study illustrated a new mechanism of glioblastoma resistance to TMZ, which based on GSCs-exo educated TAAs delivering ALKBH7 to enhance APNG expression of GBM cells, which implied that targeting on ALKBH7/APNG regulation network may provide a new strategy of enhancing TMZ therapeutic effects against glioblastoma.

Keyphrases

stem cells
poor prognosis
induced apoptosis
mesenchymal stem cells
binding protein
cell cycle arrest
signaling pathway
cell proliferation
endoplasmic reticulum stress