Nesprin1 deficiency is associated with poor prognosis of renal cell carcinoma and resistance to sunitinib treatment.

Takafumi FukushimaKohei KobatakeKento MiuraKenshiro TakemotoRyoken YamanakaRyo TasakaYuki KohadaShunsuke MiyamotoYohei SekinoHiroyuki KitanoKeisuke GotoKenichiro IkedaAkihiro GorikiKeisuke HiedaOsamu KaminumaNobuyuki Hinata

Published in: Oncology (2024)

The results indicate that the expression of SYNE1/Nesprin1 and SYNE1 mutations in patients with RCC are closely linked to their prognosis and responsiveness to sunitinib treatment.

Keyphrases

poor prognosis
renal cell carcinoma
long non coding rna
metastatic renal cell carcinoma
combination therapy