Effect of Monoamine oxidase A (MAOA) inhibitors on androgen-sensitive and castration-resistant prostate cancer cells.

Shikha GaurMitchell Eric GrossChun-Peng LiaoBin QianJean C Shih

Published in: The Prostate (2019)

MAOAIs decrease growth and proliferation of androgen-sensitive and castration-resistant prostate cancer cells. Clorgyline, in particular, decreases expression of AR-FL and AR-V7 expression and decreases growth of an enzalutamide-resistant cell line. These findings provide preclinical validation of MAOA inhibitors either alone or in combination with antiandrogens for therapeutic intent in patients with advanced forms of prostate cancer.

Keyphrases

prostate cancer
induced apoptosis
poor prognosis
cell cycle arrest
signaling pathway
stem cells
pi k akt