Lipid-Encapsulated mRNAs Encoding Complex Fusion Proteins Potentiate Antitumor Immune Responses.
Casey W ShuptrineYuhui ChenJayalakshmi MiriyalaKaren LenzDanielle MoffettThuy-Ai NguyenJenn MichauxKristen CampbellConnor SmithMarc MorraYisel Rivera-MolinaNoah Joseph MurrSarah CooperAshlyn McGuireVishruti MakaniNathan OienJeffery T ZugatesSuresh de SilvaTaylor H SchreiberSeymour de PicciottoGeorge FrommPublished in: Cancer research (2024)
Lipid nanoparticle-encapsulated mRNA can efficiently encode complex fusion proteins encompassing immune checkpoint blockers and costimulators that functionally oligomerize in vivo with extended pharmacokinetics and durable exposure to induce potent antitumor immunity.