Different expression of BRAFV600E, ALK and PD-L1 in melanoma in children and adolescents: a nationwide retrospective study in Finland in 1990-2014.

Emma K RousiIlkka O KoskivuoSusanna M JuteauLauri A I TalveMicaela M HernbergPia P VihinenVeli-Matti Kähäri

Published in: Acta oncologica (Stockholm, Sweden) (2020)

Young melanoma patients had more favorable prognosis and a different staining profile for BRAFV600E, ALK, and PD-L1 in primary tumor than reported in adults. SLNB status was not an indicator for survival. BRAFV600E-positive patients have worse prognosis and could benefit from surveillance and treatment similarly to adults.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
public health
prognostic factors
peritoneal dialysis
cross sectional
skin cancer