A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging.

Jing SuCarl EkmanNikolay OskolkovLeo LahtiKristoffer StrömAlvis BrazmaLeif GroopJohan RungOla Hansson

Published in: Skeletal muscle (2015)

These results support that mitochondrial dysfunction is a major age-related factor and also highlight the beneficial effects of maintaining a high physical capacity for prevention of age-related sarcopenia.

Keyphrases

skeletal muscle
gene expression
endothelial cells
insulin resistance
dna methylation
physical activity
induced pluripotent stem cells
mental health
single cell
pluripotent stem cells