Changes in inflammatory gene expression in brain tissue adjacent and distant to a viable cyst in a rat model for neurocysticercosis.

Rogger P Carmen-OrozcoDanitza G Dávila-VillacortaAna D Delgado-KamicheRensson H CelizGrace TrompeterGraham SutherlandCesar GavídiaHector H GarciaRobert H GilmanManuela R Verásteguinull null

Published in: PLoS neglected tropical diseases (2021)

The viable cysticerci in the rat model for NCC is characterized by increased expression of genes associated with a proinflammatory response and fibrosis-related proteins, which may mediate the chronic state of infection. These pathways appear to influence regions far from the cyst, which may explain the emerging association between NCC and hippocampal atrophy.

Keyphrases

gene expression
poor prognosis
cerebral ischemia
dna methylation
white matter
oxidative stress
binding protein
drug induced
subarachnoid hemorrhage
liver fibrosis