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Combination of Intravenous and Intra-Articular Application of Tranexamic Acid and Epsilon-Aminocaproic Acid in Primary Total Knee Arthroplasty: A Prospective Randomized Controlled Trial.

Che ZhengJun MaJiawen XuHaibo SiYuan LiuMingyang LiShen Bin
Published in: Orthopaedic surgery (2022)
Although the TBL and HB drop were slightly greater in EACA group, these results were not clinically important, given that no transfusions were required. EACA could be an alternative to TXA, especially for patients with severe nausea and vomiting after using TXA postoperatively. Further studies are needed to adjust dosage of EACA to make better comparison of the two drugs.
Keyphrases
  • total knee arthroplasty
  • randomized controlled trial
  • total hip
  • study protocol
  • high dose
  • early onset
  • drug induced
  • case control
  • systematic review
  • clinical trial
  • low dose