PARN Knockdown in Cell Lines Results in Differential and Cell-Specific Alterations in the Expression of Cancer-Associated mRNAs.

Nishith BabuPandyanda Nanjappa DechammaSandra NazarethSrividya ArjunaAnirban Chakraborty

Published in: Asian Pacific journal of cancer prevention : APJCP (2022)

The results of this study reveal that PARN deficiency leads to an altered stability of cancer-associated mRNA, distinctly, in cells of different lineages. Despite previous reports suggesting a potential therapeutic role of PARN in cancer, our results suggest that PARN may not be an important biomarker, particularly in lung cancer.

Keyphrases

single cell
induced apoptosis
poor prognosis
binding protein
cell cycle arrest
squamous cell
genome wide
cell therapy
emergency department
signaling pathway
endoplasmic reticulum stress
squamous cell carcinoma
cell death
young adults
replacement therapy
childhood cancer
pi k akt
smoking cessation