PARN Knockdown in Cell Lines Results in Differential and Cell-Specific Alterations in the Expression of Cancer-Associated mRNAs.
Nishith BabuPandyanda Nanjappa DechammaSandra NazarethSrividya ArjunaAnirban ChakrabortyPublished in: Asian Pacific journal of cancer prevention : APJCP (2022)
The results of this study reveal that PARN deficiency leads to an altered stability of cancer-associated mRNA, distinctly, in cells of different lineages. Despite previous reports suggesting a potential therapeutic role of PARN in cancer, our results suggest that PARN may not be an important biomarker, particularly in lung cancer.