Survival and health of children who are HIV-exposed uninfected: study protocol for the CHERISH (Children HIV-Exposed Uninfected - Research to Inform Survival and Health) dynamic, prospective, maternal-child cohort study.
Amy L SlogroveShani Tamlyn de BeerEmma KalkAndrew BoulleMark Fredric CottonHeinrich CupidoBarbara LaughtonMarguerite MarlowUshma MehtaNcumisa MsoloLandon MyerKathleen M PowisElisma SchoemanMark TomlinsonMoleen ZunzaPaige WilliamsMary-Ann DaviesPublished in: BMJ open (2023)
Mothers interested in joining the study are taken through a visual informed consent document for their and their child's participation, with the option to consent to anonymised de-identified data being contributed to a public data repository. All data is captured directly into an electronic database using alphanumeric identifiers devoid of identifying information. The cohort study is approved by Human Research Ethics Committees of Stellenbosch University (N20/08/084), University of Cape Town (723/2021) and Western Cape Government (WC_2021_09_007). Findings will be shared with participants, participating communities, local and provincial stakeholders, child health clinicians, researchers and policymakers at local, national and international forums and submitted for publication in peer-reviewed journals.
Keyphrases
- south africa
- hiv infected
- hiv positive
- mental health
- antiretroviral therapy
- public health
- healthcare
- big data
- electronic health record
- human immunodeficiency virus
- young adults
- health information
- hepatitis c virus
- hiv testing
- hiv aids
- endothelial cells
- randomized controlled trial
- palliative care
- free survival
- artificial intelligence
- systematic review
- dna repair
- data analysis
- emergency department
- human health
- oxidative stress
- quality improvement
- risk assessment