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Relationship between HDL Cholesterol Efflux Capacity, Calcium Coronary Artery Content, and Antibodies against ApolipoproteinA-1 in Obese and Healthy Subjects.

Nicolas VuilleumierSabrina PaganoFabrizio MontecuccoAlessandra QuercioliThomas Hellmuth SchindlerFrançois MachEleonora CipollariNicoletta RondaElda Favari
Published in: Journal of clinical medicine (2019)
We report a paradoxical positive association between ABCA1-CEC and the CAC score, with the latter being inversely associated with PD in OS. Corroborating our clinical observations, anti-apoA-1 IgG enhanced ABCA1 while repressing PD-CEC, leading to MCC increase in vitro. These results indicate that anti-apoA-1 IgG have the potential to interfere with CEC and macrophage lipid metabolism, and may underpin paradoxical associations between ABCA1-CEC and cardiovascular risk.
Keyphrases
  • coronary artery
  • adipose tissue
  • pulmonary artery
  • type diabetes
  • metabolic syndrome
  • pulmonary hypertension
  • bariatric surgery
  • risk assessment
  • fatty acid