Serum neurofilament light chain in pediatric spinal muscular atrophy patients and healthy children.

Elisa NitzMartin SmitkaJens SchallnerKatja AkgünTjalf ZiemssenMaja von der HagenVictoria Tüngler

Published in: Annals of clinical and translational neurology (2021)

Reference sNfL values of our large pediatric control cohort may be applied for future studies. Strong correlations between sNfL and cNfL together with motor function suggest that sNfL may be a suitable biomarker for disease activity in children with 2 SMN2 copies and those with >2 SMN2 copies within their initial stages during early childhood.

Keyphrases

disease activity
rheumatoid arthritis
systemic lupus erythematosus
end stage renal disease
young adults
ejection fraction
rheumatoid arthritis patients
newly diagnosed
chronic kidney disease
ankylosing spondylitis
peritoneal dialysis
current status
patient reported outcomes
patient reported
childhood cancer