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Diurnal and circadian rhythmicity of the human blood transcriptome overlaps with organ- and tissue-specific expression of a non-human primate.

Carla Sofia Möller-LevetEmma E LaingSimon N ArcherDerk-Jan Dijk
Published in: BMC biology (2022)
The human blood transcriptome contains sets of rhythmic genes that overlap with rhythmic genes of tissues/organs in baboon. The rhythmic sets vary across tissues/organs, but the timing of most rhythmic genes is similar in human blood and baboon tissues/organs. These results have implications for development of blood transcriptome-based biomarkers for circadian rhythmicity in tissues and organs.
Keyphrases
  • endothelial cells
  • gene expression
  • genome wide
  • induced pluripotent stem cells
  • pluripotent stem cells
  • genome wide analysis