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A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line.

Jéssica D SilvaJoana MarquesInês P SantosAna L M Batista de CarvalhoClara B MartinsRaquel C LaginhaLuís A E Batista de CarvalhoMaria Paula M Marques
Published in: Molecules (Basel, Switzerland) (2023)
A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt 2 Put 2 (NH 3 ) 4 ]Cl 4 ) was synthesized and assessed as to its potential anticancer activity against a human non-small cell lung cancer line (A549), as well as towards non-cancer cells (BEAS-2B). This effect was evaluated through in vitro cytotoxicity assays (MTT and SRB) coupled to microFTIR and microRaman spectroscopies, the former delivering information on growth-inhibiting and cytotoxic abilities while the latter provided very specific information on the metabolic impact of the metal agent (at the sub-cellular level). Regarding cancer cells, a major impact of [Pt 2 Put 2 (NH 3 ) 4 ]Cl 4 was evidenced on cellular proteins and lipids, as compared to DNA, particularly via the Amide I and Amide II signals. The effect of the chelate on non-malignant cells was lower than on malignant ones, evidencing a promising low toxicity towards healthy cells.
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