Sex-specific differences in clot resolution 3 weeks after acute pulmonary embolism managed with anticoagulants-A substudy of the EINSTEIN-PE study.
Hanke M G WiegersJosien van EsÁkos F PapAnthonie W A LensingSaskia MiddeldorpLuuk J J ScheresPublished in: Journal of thrombosis and haemostasis : JTH (2021)
A total of 371 participants including 174 (46.9%) women and 197 (53.0%) men were included in the present analysis. At 3 weeks, there was no difference between men and women in complete clot resolution: 39.6% and 40.2%, respectively. The absolute reduction in pulmonary vascular obstruction at week 3 was also similar: 12.9% (95% confidence interval [CI]: 11.6-14.2) in men and 12.1% (95% CI: 10.4-13.7) in women, corresponding to a resolution ratio of 0.29 (95% CI: 0.24-0.33) and 0.35 (95% CI: 0.28-0.42), respectively. No differences in clot resolution were observed between men and women diagnosed with acute PE at 3 weeks after start of anticoagulant therapy. These findings suggest that the reported higher rate of VTE recurrence in men cannot be explained by decreased clot resolution.
Keyphrases
- pulmonary embolism
- single molecule
- venous thromboembolism
- polycystic ovary syndrome
- inferior vena cava
- gestational age
- atrial fibrillation
- type diabetes
- stem cells
- randomized controlled trial
- adipose tissue
- insulin resistance
- respiratory failure
- drug induced
- extracorporeal membrane oxygenation
- cell therapy
- double blind