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Flomoxef for neonates: extending options for treatment of neonatal sepsis caused by ESBL-producing Enterobacterales.

Christopher A DarlowWilliam Hope
Published in: The Journal of antimicrobial chemotherapy (2022)
To the best of our knowledge, this is the first published neonatal PopPK model for flomoxef. Given the high treatment success rates, low toxicity rates and off-patent status, this drug has potential for use in the treatment of neonatal sepsis in ESBL-prevalent LMIC settings.
Keyphrases
  • escherichia coli
  • intensive care unit
  • healthcare
  • acute kidney injury
  • randomized controlled trial
  • systematic review
  • oxidative stress
  • risk assessment
  • multidrug resistant
  • klebsiella pneumoniae
  • replacement therapy