The Concentration of Metronidazole in the Distal Interphalangeal Joint following Intravenous Regional Limb Perfusion via the Cephalic Vein in Standing Horses.
Kajsa GustafssonAmos J TatzRoee DahanMalka BritziStefan SobackWiessam Abu AhmadHagar PrinceGal KelmerPublished in: Veterinary and comparative orthopaedics and traumatology : V.C.O.T (2021)
Metronidazole administered by IVRLP reached high concentrations in the synovial fluid at 0.5 hours. However, the concentrations rapidly decreased below the minimum inhibitory concentration of potential target pathogens. Effectiveness of metronidazole administered by IVRLP as a sole therapy against anaerobic infections of synovial structures of the distal limb cannot be determined by a pharmacokinetic study. However, the present study serves as the basis for future carefully planned clinical trials.