PathTracer Comprehensively Identifies Hypoxia-Induced Dormancy Adaptations in Mycobacterium tuberculosis .
Ushashi BanerjeeAdithya ChedereRaksha PadakiAbhilash MohanNarmada SambaturuAmit SinghNagasuma ChandraPublished in: Journal of chemical information and modeling (2023)
Mining large-scale data to discover biologically relevant information remains a challenge despite the rapid development of bioinformatics tools. Here, we have developed a new tool, PathTracer, to identify biologically relevant information flows by mining genome-wide protein-protein interaction networks following integration of gene expression data. PathTracer successfully mines interactions between genes and traces the most perturbed paths of perceived activities under the conditions of the study. We further demonstrated the utility of this tool by identifying adaptation mechanisms of hypoxia-induced dormancy in Mycobacterium tuberculosis (Mtb).
Keyphrases
- mycobacterium tuberculosis
- genome wide
- dna methylation
- protein protein
- gene expression
- pulmonary tuberculosis
- electronic health record
- small molecule
- big data
- copy number
- physical activity
- depressive symptoms
- social support
- mental health
- healthcare
- data analysis
- artificial intelligence
- machine learning
- loop mediated isothermal amplification
- sensitive detection