Giving Breath to Motor Neurons: Noninvasive Mechanical Ventilation Slows Disease Progression in Amyotrophic Lateral Sclerosis.
Maurizio GrassanoEmanuele KoumantakisUmberto ManeraAntonio CanosaRosario VastaFrancesca PalumboGiuseppe FudaPaolina SalamoneGiulia MarcheseFederico CasaleLorena CharrierGabriele MoraCristina MogliaAndrea CalvoAdriano ChiòPublished in: Annals of neurology (2024)
NIMV significantly influences the rate of motor progression in ALS, and this effect is not determined by the nonlinearity of ALSFRS-R trajectory. The functional decline slowed following NIMV initiation, independently of the site of disease onset or disease severity at the time of NIMV initiation. Our findings underscore the importance of timely NIMV initiation for all ALS patients and highlight the need to consider NIMV-induced slowing of disease progression when evaluating clinical trial outcomes. ANN NEUROL 2024;95:817-822.
Keyphrases
- mechanical ventilation
- clinical trial
- end stage renal disease
- acute respiratory distress syndrome
- chronic kidney disease
- newly diagnosed
- ejection fraction
- intensive care unit
- peritoneal dialysis
- amyotrophic lateral sclerosis
- spinal cord
- randomized controlled trial
- type diabetes
- diabetic rats
- metabolic syndrome
- patient reported outcomes
- skeletal muscle
- drug induced
- spinal cord injury
- insulin resistance
- double blind
- glycemic control
- phase iii