Human Umbilical Cord Mesenchymal Stem Cells Attenuate Severe Burn-Induced Multiple Organ Injury via Potentiating IGF-1 and BCL-2/BAX Pathway.

Hongyu Wang Te Ba Qiong Wang Longlong Yang Chenyi Li Xingxia Hao Yue Yin Lingying Liu

Published in: Stem cells international (2022)

The hUCMSCs transplantation can attenuate severe burn-induced early organ injuries and protect multiorgan functions by encouraging migration of hUCMSCs with blood circulation and increasing protective cytokine IGF-1 level and regulating BCL-2/BAX pathway of these vital organs. Furthermore, these data might provide the theoretical foundation for further clinical applications of hUCMSCs in burn areas.

Keyphrases

mesenchymal stem cells
umbilical cord
high glucose
endothelial cells
drug induced
diabetic rats
cell therapy
early onset
binding protein
bone marrow
electronic health record
pi k akt
cell proliferation
pluripotent stem cells