Can maternal treatment with metformin during gestation and lactation cause metabolic and cardiovascular disorders in rat offspring?
Daniella R B S NoviCamila B VidigalBruno V D MarquesSimone ForcatoHiviny A RaquelDimas A M ZaiaCássia T B V ZaiaMarli Cardoso Martins-PingeDaniela C C GerardinGraziela Scalianti CeravoloPublished in: Archives of physiology and biochemistry (2018)
Objective: The aim was to evaluate if maternal treatment with metformin (MET) during pregnancy and lactation could be safe for metabolic and cardiovascular parameters of adult male and female offspring.Materials and methods: Wistar female rats were treated with MET (293 mg/kg/d) or tap water, by gavage during gestation (METG or CTRG) or gestation and lactation (METGL or CTRGL).Results: At 75 days of life, male and female MET offspring presented similar blood pressure when compared with their CTR. The heart rate of female METGL was higher than in the CTRGL. The insulin sensitivity, basal glycaemia, body weight, Lee index of obesity, plasmatic concentration of triglycerides, total cholesterol and fat acid of male and female MET were similar to CTR groups. Lower fat pad deposition was observed in female METG and METGL.Conclusion: MET exposure during gestational and lactation does not program cardiovascular and metabolic alterations in adult offspring life.
Keyphrases
- heart rate
- blood pressure
- human milk
- high fat diet
- tyrosine kinase
- dairy cows
- body weight
- preterm infants
- birth weight
- gestational age
- adipose tissue
- weight gain
- heart rate variability
- insulin resistance
- low birth weight
- pregnant women
- type diabetes
- metabolic syndrome
- fatty acid
- body mass index
- physical activity
- quality improvement
- skeletal muscle
- combination therapy
- high density
- young adults
- newly diagnosed