Directional Endothelial Communication by Polarized Extracellular Vesicle Release.
Sneha RajuSteven R BottsMark C BlaserMajed Abdul-SamadKamalben PrajapatiNegar KhosravianiTse Wing Winnie HoLeandro C D BredaCrizza ChingNatalie J GalantLindsey FiddesRuilin WuCassandra L CliftTan PhamWarren L LeeSasha A SinghElena AikawaJason E FishKathryn L HowePublished in: Circulation research (2024)
Demonstrating that ECs are capable of polarized EV cargo loading and directional EV secretion reveals a novel paradigm for endothelial communication, which may ultimately enhance the design of endothelial-based therapeutics for cardiovascular diseases such as atherosclerosis where ECs are persistently activated.