Longitudinal Changes in Blood Biomarkers of Clinical Alzheimer Disease in a Biracial Population Sample.
Kumar RajanElizabeth A McAninchNeelum AggarwalLisa L BarnesRobert WilsonJennifer WeuveCharles S DeCarliDenis EvansPublished in: Neurology (2022)
Blood biomarkers showed significant longitudinal changes corresponding to cognitive decline, clinical AD, and structural MRI characteristics. Our findings show that longitudinal changes in serum biomarkers were associated with several cognitive endophenotypes. GLOSSARY: t-tau= total tau; Nf-L= Neurofilament Light; GFAP= Glial Fibrillary Acidic Protein; AD= Alzheimer's disease; MRI= Magnetic Resonance Imaging; CI = Confidence Interval CLASSIFICATION OF EVIDENCE: The study found Class II evidence that longitudinal changes in serum t-tau, Nf-L, and GFAP were associated with cognitive decline and the development of clinical AD in people over age 65.
Keyphrases
- cognitive decline
- mild cognitive impairment
- magnetic resonance imaging
- cerebrospinal fluid
- contrast enhanced
- cross sectional
- signaling pathway
- computed tomography
- oxidative stress
- machine learning
- deep learning
- lps induced
- diffusion weighted imaging
- magnetic resonance
- nuclear factor
- immune response
- ionic liquid
- amino acid