Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia.
Gael GenetNafiisha GenetUmadevi PailaShelby R CainAleksandra CwiekNicholas W ChavkinVlad SerbuleaAgnès FiguerasPau CerdàStephanie P McDonnellDanya SankaranarayananMahalia HubaElizabeth A NelsonAntoni Riera-MestreKaren K HirschiPublished in: Circulation (2023)
This study provides new insights into molecular mechanisms leading to HHT by defining how endothelial cell cycle is dysregulated in AVMs because of BMP9/10 and Alk1 signaling deficiencies, and how restoration of endothelial cell cycle control may be used to treat AVMs in patients with HHT.